RESEARCH THEMES

Our lab is Applying Nano & Microfabrication Techniques in the Manufacturing of Drug Delivery Systems, Medical Devices and Implants.

Our Lab is emerging new materials and manufacturing techniques, in order to address the challenges associated with the manufacture of pharmaceutical systems that will teach new tricks to old drugs and on the development of new personalised medical devices and implants.

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ADDITIVE MANUFACTURING

  1. Manufacturing of novel drug delivery systems & medical devices (e.g., catheters, drug eluting vascular grafts, implants for long-acting drug delivery, surgical meshes, microneedles) using innovative 3D printing technologies. 

  2. 3D Bioprinting applications in pharmaceutics and tissue engineering (e.g., arterial regeneration, bioresorbable vascular scaffolds, cardiac patches, wound healing).

  3. In-house prepared Bio-inks using natural or synthetic polymers, and preparation of drug-loaded or empty filaments by hot-melt extrusion (HME).


Recognised as world leaders in Printing. PubMed-based algorithms placed us in the top 0.1% of scholars in the world writing about Printing over the past 10 years.

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ELECTROHYDRODYNAMIC PROCESSES 

Manufacturing of nanofibers by electrospinning (melt or solution) for a variety of drug delivery and tissue engineering applications (e.g., cardiac patches, long-acting implantable devices, oral films, surgical mesh implants, wound healing).

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MICROFLUIDICS & LAB-ON-A-CHIP

  1. Manufacturing of Polymer (e.g., PLGA) & lipid-based (e.g., liposomes, SLNs) Nanomedicines using microfluidics and comparison with traditional formulation methods (e.g., extrusion, thin-film hydration) for imaging or treatment or targeting using new or currently available drugs & biologics; including surface modification for cancer treatment/targeting.

  2. In-house fabrication of microfluidic chips (Lab-on-a-chip) for Pharmaceutical Applications (e.g. Drug Delivery, Drug Screening) by 3D printing and soft photolithography.

PubMed-based algorithms placed us in the top 5 labs in UK in the area of Microfluidics. 

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OUR STUDIES INCLUDE 

  1. Formulation, physicochemical characterization, computational modelling (e.g. Finite Element Analysis (FEA), Computational Fluid Dynamics (CFD)), and in vitro & in vivo evaluation.

  2. The use of Microelectromechanical Systems (MEMS & BioMEMS) as point-of-care (PoC) diagnostic devices, biosensors, and drug delivery devices, in combination with 3D Printed or Microfluidic systems.

  3. The lab research involves both the study of material characteristics as well as the application of such knowledge to the design and manufacture of pharmaceutical products & medical devices/implants, including the implementation of concepts such as Scaling-up, Continuous Manufacturing, Quality by Design (QbD) & Process Analytical Technology (PAT; e.g., NIR, MiR, Raman, and UV probes), and the use of Nanocharacterisation Techniques (e.g., AFM, μCT, ToF-SIMS, XPS).

If you want to learn more about our research, please don’t hesitate to get in touch.