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RESEARCH THEMES

Our lab is Applying Nano & Microfabrication Techniques in the Manufacturing of Drug Delivery Systems, Medical Devices and Implants.

Our Lab is emerging new materials and manufacturing techniques, in order to address the challenges associated with the manufacture of pharmaceutical systems that will teach new tricks to old drugs and on the development of new personalised medical devices and implants.

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ADDITIVE MANUFACTURING

Our AM research is focusing on the development of AM equipment & processes, in materials for drug delivery applications & implants, in Bioprinting, and in printing for medications.

  1. Manufacturing of novel drug delivery systems & medical devices (e.g., catheters, drug eluting vascular grafts, implants for long-acting drug delivery, surgical meshes, microneedles, oral dosage forms) using innovative 3D printing technologies. 

  2. 3D Bioprinting applications in pharmaceutics and tissue engineering (e.g., arterial regeneration, bioresorbable vascular scaffolds, cardiac patches, wound healing).

  3. 4D printing systems for the manufacturing of scaffolds, implants, and targeted drug delivery systems.

  4. Bioinks & Filaments: In-house prepared Bio-inks using natural or synthetic polymers, and preparation of drug-loaded or empty filaments by hot-melt extrusion (HME).


Recognised as world leaders in Printing. PubMed-based algorithms placed us in the top 0.1% of scholars in the world writing about Printing over the past 10 years.

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ELECTROHYDRODYNAMIC PROCESSES 

  1. Manufacturing of medical nanofibers by electrospinning (melt or solution) for a variety of drug delivery and tissue engineering applications (e.g., cardiac patches, long-acting implantable devices, oral films, solid dispersions, surgical mesh implants, wound healing).

  2. Electrospray: coating of implants (e.g., stents) or preparation of microparticles. 

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MICROFLUIDICS & LAB-ON-A-CHIP

  1. Manufacturing of Polymer (e.g., PLGA) & lipid-based (e.g., liposomes, Solid lipid nanoparticles, niosomes) Nanomedicines using microfluidics and comparison with traditional formulation methods (e.g., extrusion, thin-film hydration) for imaging or treatment or targeting using new or currently available drugs & biologics; including surface modification for cancer treatment/targeting.

  2. In-house fabrication of microfluidic chips (including Lab-on-a-chip | Organ-on-a-chip) for Pharmaceutical Applications (e.g., Drug Delivery, Drug Screening) by 3D printing and soft photolithography.

PubMed-based algorithms placed us in the top 5 labs in UK in the area of Microfluidics. 

Image by Dan-Cristian Pădureț

POC & BIOSENSORS

Use of Microelectromechanical Systems (MEMS) & BioMEMS as point-of-care (PoC) diagnostic devices, biosensors, and drug delivery devices, in combination with 3D Printed (e.g., Microneedles) or Microfluidic systems.

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OUR STUDIES INCLUDE 

  1. From formulation to in vivo analysis: Formulation, physicochemical characterization, computational modelling (e.g. Finite Element Analysis (FEA), Computational Fluid Dynamics (CFD)), and in vitro, ex vivoin vivo evaluation.

  2. Implementation of concepts such as Scaling-up, Continuous Manufacturing, Quality by Design (QbD) & Process Analytical Technology (PAT; e.g., NIR, MiR, Raman, and UV probes).

  3. Machine Learning /  Artificial Intelligence: variety of methods in Additive Manufacturing and Microfluidics. 

  4. Advanced Characterisation: Use of state-of-the-art Nanocharacterisation techniques (e.g., AFM, μCT, ToF-SIMS, XPS).

  5. Sustainability & Supply-Chain: The lab is a Sustainable Lab and has received the Sustainable Lab Awards Silver S-Lab & is engaged in the pilot lab sustainability program LEAF.

If you want to learn more about our research, please don’t hesitate to get in touch.