RESEARCH INTERESTS

Our lab is Applying Nano & Microfabrication Techniques in the Manufacturing of Drug Delivery Systems, Medical Devices and Implants.

Our Lab is emerging new materials and manufacturing techniques, in order to address the challenges associated with the manufacture of pharmaceutical systems that will teach new tricks to old drugs and on the development of new personalised medical devices and implants.

HME.jpg

ADDITIVE MANUFACTURING

  1. Manufacturing of novel drug delivery systems & medical devices (e.g., catheters, drug eluting vascular grafts, implants for long-acting drug delivery, surgical meshes, microneedles) using innovative 3D printing technologies; including in-house prepared filaments by hot-melt extrusion (HME).

  2. 3D Bioprinting applications in pharmaceutics and tissue engineering (e.g., arterial regeneration, bioresorbable vascular scaffolds, cardiac patches, wound healing). 

Electrospinning_edited.png

ELECTROSPINNING (MELT & SOLUTION)

Manufacturing of nanofibers for a variety of drug delivery and tissue engineering applications (e.g., cardiac patches, long-acting implantable devices, oral films, surgical mesh implants, wound healing).

Microfluidic.jpg

MICROFLUIDICS & MICROFLUIDIC DEVICES

  1. Manufacturing of Polymer (e.g., PLGA) & lipid-based (e.g., liposomes, SLNs) Nanomedicines using microfluidics and comparison with traditional formulation methods (e.g., extrusion, thin-film hydration) for imaging or treatment or targeting using new or currently available drugs & biologics; including surface modification for cancer treatment/targeting.

  2. In-house fabrication of microfluidic chips (Lab-on-a-chip) for Pharmaceutical Applications (e.g. Drug Delivery, Drug Screening) by 3D printing and soft photolithography.

Micro Chip

OUR STUDIES INCLUDE 

  1. Formulation, physicochemical characterization, computational modelling (e.g. Finite Element Analysis (FEA), Computational Fluid Dynamics (CFD)), and in vitro & in vivo evaluation.

  2. The use of Microelectromechanical Systems (MEMS & BioMEMS) as point-of-care (PoC) diagnostic devices, biosensors, and drug delivery devices, in combination with 3D Printed or Microfluidic systems.

  3. The lab research involves both the study of material characteristics as well as the application of such knowledge to the design and manufacture of pharmaceutical products & medical devices/implants, including the implementation of concepts such as Scaling-up, Continuous Manufacturing, Quality by Design (QbD) & Process Analytical Technology (PAT; e.g., NIR, MiR, Raman, and UV probes), and the use of Nanocharacterisation Techniques (e.g., AFM, μCT, ToF-SIMS, XPS).

If you want to learn more about our research, please don’t hesitate to get in touch.